In News:

Researchers from Nagaland University have identified Sinapic acid, a naturally occurring plant compound, as a potential therapeutic agent for accelerating wound healing in diabetic patients. The study — the first globally to demonstrate its oral efficacy — has been published in Nature Scientific Reports (Springer Nature).

About Sinapic Acid

• Chemical Nature:Sinapic acid is a natural phenolic acid and a derivative of cinnamic acid.
• Occurrence:Found widely in spices, citrus and berry fruits, vegetables, cereals, and oilseed crops.
• Properties:Possesses antioxidant, anti-inflammatory, antitumor, antibacterial, and neuroprotective activities.
• Mechanism of Action:The compound promotes wound repair by activating the SIRT1 pathway, which regulates tissue regeneration, angiogenesis, and inflammation control.

Key Research Findings

• First-of-its-kind Study:Demonstrated that oral administration of Sinapic acid accelerates wound healing in preclinical diabetic models.
• Optimal Dosage:The study observed an “inverted dose–response” — a lower dose (20 mg/kg) proved more effective than a higher one (40 mg/kg).
• Clinical Significance:
  • Accelerates recovery from diabetic foot ulcers
  • Reduces the risk of infection and amputation
  • Offers a safe, plant-based, and affordable alternative to synthetic drugs
  • Could enhance healthcare accessibility, especially in rural and resource-limited regions

About Diabetes Mellitus

• A metabolic disorder characterized by chronically elevated blood glucose levels.
• One of the world’s leading chronic diseases, affecting hundreds of millions globally.
• Complications:Include delayed wound healing, neuropathy, poor blood circulation, and diabetic foot ulcers, often resulting in amputation if untreated.

Significance of the Discovery

• Represents an indigenous scientific advancement with global healthcare potential.
• Supports the Make-in-India and One Health approach by integrating biotechnology and natural product research for sustainable medical solutions.
• Marks a major milestone in developing natural, safe, and cost-effective treatments for diabetic wound management.